杜文娟

      杜文娟，女，博士，研究员，获国家海外高层次人才引进计划青年项目（2023）支持，荷兰皇家微生物学会会员，致力于流感病毒和冠状病毒等人畜共患病病原的入侵与跨种传播机制以及防控策略研究。科研成果以第一作者身份发表于Nature Communications, Science Immunology，Plos Pathogens, mBio, Journal of Virology, The FEBS Journal
等国际权威期刊 人畜共患病病毒的入侵和抗病毒研究
2024.04-至今       河南农业大学 研究员
2020.07-2024.06 荷兰乌特勒支大学 博士后
2016年至今-荷兰皇家微生物学会会员
Frontiers in Cellular and Infection Microbiology，npj viruses 杂志审稿人
1.国家海外高层次人才引进计划青年项目 2024-2027 主持
1.  Du W, Debski-Antoniak O, Drabek D, van Haperen R, van Dortmond M, van der Lee J, Drulyte I, van Kuppeveld FJM, Grosveld F, Hurdiss DL, Bosch BJ. (2024) Neutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein. Nature Communications  （online publication）
2.  Du W, Hurdiss DL, Drabek D, Mykytyn AZ, Kaiser FK, González-Hernández M, Muñoz-Santos D, Lamers MM, van Haperen R, Li W, Drulyte I, Wang C, Sola I, Armando F, Beythien G, Ciurkiewicz M, Baumgärtner W, Guilfoyle K, Smits T, van der Lee J, van Kuppeveld FJM, van Amerongen G, Haagmans BL, Enjuanes L, Osterhaus ADME, Grosveld F, Bosch BJ. (2022) An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern. Science Immunology. 7(73): eabp9312.
3.  Du W, Wolfert M, Peeters B, van Kuppeveld F, Boons G, de Vries E, de Haan C. (2020) Crosstalk between the receptor-binding properties of influenza A virus hemagglutinin and neuraminidase drives their co-evolution. Plos Pathogens:e1008816.
4.  Du W, Guo H, Nijman V, Doedt J, de Vries E, van der Lee J, Li Z, Boons G, van Kuppeveld F, de Vries E, Matrosovich M, de Haan C. (2019) The 2nd Sialic Acid-Binding Site of Influenza A Virus Neuraminidase Is an Important Determinant of the Hemagglutinin-Neuraminidase-Receptor Balance. Plos Pathogens e1007860.
5.  Du W, Dai M, Li Z, Boons G, Peeters B, van Kuppeveld F, de Vries E, de Haan C. (2018) Substrate Binding by the Second Sialic Acid-Binding Site of Influenza A Virus N1 Neuraminidase Contributes to Enzymatic Activity. Journal of Virology. 92(20): e01243-18.
6.  Du W, de Vries E, van Kuppeveld F, Matrosovich M, de Haan C. (2021) Second sialic acid-binding site of influenza A virus neuraminidase: binding receptors for efficient release. The FEBS Journal. 288(19):5598-5612. Think big and dream even bigger