庄国庆

姓名：庄国庆
学科：预防兽医学
系别：预防兽医系
电话/传真：
电子邮件：gqzhuang2008@163.com
通讯地址：郑州市郑东新区龙子湖高校园区15号 河南农业大学龙子湖校区第一实验楼动物医学院 450046

 

      庄国庆，男，博士，特聘教授，博士生导师，国家动物免疫学国际联合研究中心副主任，山东潍坊人。主讲本科生《畜牧微生物学》、《生物技术制药》、《生物安全》；研究生《传染病与生物制品学》、《兽医学进展》等课程。参与编写普通高等教育农业部“十三五”规划教材《兽医传染病学》等书目。
      科研方向为畜禽病毒致病分子机制及疫苗研发。目前主持和参与国家自然科学基金非洲猪瘟专项项目；国家“十四五”重点研发计划；河南省2020年度留学回国人员科研择优项目；河南农业大学海外高层次“拔尖人才”计划等项目。教育部学位评审专家；科技部专家库成员；担任《Frontiers in Immunology》、《Veterinary Microbiology》、《Viruses》、《Frontiers in Microbiology》、《Microorgnisms》、《中国农业科学》、《畜牧兽医学报》和《河南农业科学》等期刊审稿人。
     科研成果主要发表于Circulation、The Journal of Clinical Investigation、Veterinary Research、Veterinary Microbiology、Viruses、BMC genomics等期刊杂志30余篇。先后获得河南省教育厅优秀科技论文奖1等奖，河南省人力资源与保障厅自然科学优秀学术论文奖2等奖，申报国家发明专利1项，主编（副主编）专著1部。
本科生《生物技术制药》、《畜牧微生物学》、《生物安全》
研究生《传染病与生物制品学》、《兽医学进展》
畜禽病毒致病分子机制及疫苗研发
2007年3月-2010年3月 中国科学院大学，生物学，博士
2003年9月-2006年6月 山东农业大学预防兽医学，硕士
1999年9月-2003年6月 山东农业大学，本科
2017年10月-至今，特聘教授，河南农业大学
2010年4月-2017年9月，博士后，美国德州农工大学 
2006年8月-2007年3月，研究助理，中国科学院大学
美国微生物学会会员、美国科学促进学会会员、河南省微生物学会会员；《Frontiers in Immunology》、《Veterinary Microbiology》、《Viruses》、《Frontiers in Microbiology》、《Microorgnisms》、《Virulence》《中国农业科学》、《畜牧兽医学报》、和《河南农业科学》等杂志审稿人
1. 科技部，“十四五”国家重点研发计划，非洲猪瘟活载体疫苗研发（2021YFD1801404），2021.01-2023.12，主持
2. 国家自然基金委员会，国家自然基金专项项目，非洲猪瘟治疗性药物/抗体开发及其作用机制（31941016），2020.01-2022.12，主持
3. 河南省人力资源与社会保障厅，2020年度留学人员科研择优项目，新型马立克氏病病毒基因重组疫苗研发（30602136），2020.08-2021.08，主持
4. 河南农业大学，拔尖人才项目，表观遗传学在动物病毒致病过程中的作用机制研究（30500690），2018.09-2023.09，主持
5. 国家自然基金委员会，国家自然基金专项项目，非洲猪瘟病毒主要免疫原的识别与疫苗靶点发现研究（31941001），2019.06-2022.06，参加
6. 中国工程院院地合作项目，中亚五国养殖业与疫病防控合作的战略研究（201903ZDA04），2019.01-2020.12，参加
7. 国家自然基金委员会，国家自然基金青年项目，马立克氏病病毒编码miRNA基因簇3在病毒致病过程中分子调控机制研究（31802160），2019.01-2021.12，参加
1. Shuai Zhang; Rui Wang; Xiaojing Zhu; Jiaxin Jin; Wenlong Lu; Xuyang Zhao; Bo Wan; Yifei Liao; Qin Zhao; Christopher L.Netherton; Guoqing Zhuang*; Aijun Sun*; Gaiping Zhang*. Identification and characterization of a novel epitope of ASFV-encoded dUTPase by monoclonal antibodies. Viruses, 2021,13(11):2175.
2.  Shuaikang Yang#; Yifei Liao#; Shuai Zhang; Wenlong Lu; Jiaxin Jin; Man Teng; Shujun Chai; Jun Luo; Gaiping Zhang; Aijun Sun*; Guoqing Zhuang*. Marek's disease virus encoded miR-M6 and miR-M10 are dispensable for virus replication and pathogenesis in chickens. Veterinary Microbiology, 2021,262:109248.
3.  Aijun Sun; Shuaikang Yang; Jun Luo; Man Teng; Yijie Xu; Rui Wang; Xiaojing Zhu; Luping Zheng; Yanan Wu; Yongxiu Yao; Venugopal Nair; Gaiping Zhang; Guoqing Zhuang*. UL28 and UL33 homologs of Marek’s disease virus terminase complex involved in the regulation of cleavage and packaging of viral DNA are indispensable for replication in cultured cells, Veterinary Research, 2021, 52(1): 20. 
4.  Aijun Sun; Yifei Liao; Ying Liu; Shuaikang Yang; Xiangru Wang; Xiaojing Zhu; Man Teng; Shujun Chai; Jun Luo; Gaiping Zhang; Guoqing Zhuang*. Virus-encoded microRNA-M7 restricts early cytolytic replication and pathogenesis of Marek’s disease virus, Veterinary Microbiology, 2021,259：109082.
5.  Aijun Sun#; Xiaojing Zhu#; Ying Liu; Rui Wang; Shuaikang Yang; Man Teng; Luping Zheng; Jun Luo; Gaiping Zhang; Guoqing Zhuang*. Transcriptome-wide N6-methyladenosine modification profiling of long non-coding RNAs during growth of Marek’s disease virus in vitro, BMC Genomics, 2021,22(1):296.
6. Aijun Sun#; Rui Wang#; Shuaikang Yang; Xiaojing Zhu; Ying Liu; Man Teng; Luping Zheng; Jun Luo; Gaiping Zhang; Guoqing Zhuang*. Comprehensive profiling analysis of the N6-methyladenosine-modified circular RNA transcriptome in cultured cells infected with Marek’s disease virus, Scientific Reports, 2021,11(1):11084.
7.  Yifei Liao#; Aijun Sun#; Guoqing Zhuang; Blanca Lupiani; Sanjay M. Reddy*. Deletion of LORF9 but not LORF10 attenuates Marek’s disease virus pathogenesis, Veterinary Microbiology, 2020, 251: 108911. 
8.  Shuai Zhang; Aijun Sun; Bo Wan; Yongkun Du; Yanan Wu; Angke Zhang; Dawei Jiang; Pengchao Ji; Zhanyong Wei; Guoqing Zhuang*; Gaiping Zhang*. Development of a Directly Visualized Recombinase Polymerase Amplification-SYBR Green I Method for the Rapid Detection of African Swine Fever Virus, Frontiers in Microbiology, 2020, 11:602709.
9.  Yifei Liao#; Guoqing Zhuang#; Aijun Sun; Owais A.Khan; Lupiani Blanca; Sanjay M.Reddy*. Marek's Disease Virus Cluster 3 miRNAs Restrict Virus' Early Cytolytic Replication and Pathogenesis.Viruses, Viruses, 2020, 12(11):1317. 
10.  Aijun Sun; Jun Luo; Bo Wan; Yongkun Du; Xiangru Wang; Haoyu Weng;   Xinru Cao; Tianlu Zhang; Shujun Chai; Dong Zhao; Guangxu Xing; Guoqing Zhuang*; Gaiping Zhang*. Lorf9 deletion significantly eliminated lymphoid organ atrophy induced by meq-deleted very virulent Marek’s disease virus, Veterinary Microbiology, 2019, 235: 164-169. 
11.  Guoqing Zhuang; Aijun Sun; Man Teng; Jun Luo*. A Tiny RNA that Packs a Big Punch: The Critical Role of a Viral miR-155 Ortholog in Lymphomagenesis in Marek's Disease, Frontiers in Microbiology, 2017, 8:1169.
12.  Man Teng; Zuhua Yu; Pu Zhao; Guoqing Zhuang; Zixiang Wu; Lu Dang; Huizhen Li; Shengming Ma; Zhizhong Cui; Gaiping Zhang; Run Wu*; Jun Luo*. Putative roles as oncogene or tumour suppressor of the Mid-clustered microRNAs in Gallid alphaherpesvirus 2 (GaHV2) induced Marek's disease lymphomagenesis.J Gen Virol, 2017, 98(5):1097-1112.
13.  Guoqing Zhuang; Youxin Wang*. A Tiny RNA Molecule with a Big Impact on Type 2 Diabetes Mellitus Susceptibility. Biomed Environ Sci, 2017,30(11):855-861. 
14.  Wei Ying#; Alexander Tseng#; Richard Cheng-An Chang; Andrew Morin; Tyler Brehm; Karen Triff; Vijayalekshmi Nair; Guoqing Zhuang; Hui Song; Srikanth Kanameni; Haiqing Wang; Michael C.Golding; Fuller W.Bazer; Robert S.Chapkin; Stephen Safe; Beiyan Zhou*. microRNA-223 is a crucial mediator for PPARγ-regulated macrophage alternative activation. Journal of Clinical Investigation, 2015,125(11): 4149-59. 
15.  Marina Bousquet, Guoqing Zhuang, Cong Meng, Wei Ying, Patail Cheruku, Andrew Shie, Stephanie Wang, Guangtao Ge, Gang Wang, Safe Stephen and Beiyan Zhou*. miR-150 blocks MLL-AF9-associated leukemia through oncogene repression. Molecular Cancer Research, 2013,11(8): 912-922. 
16.  Yuxiang Zhang; Yan Liu; Jing Dong; Youxin Wang; Jing Wang; Guoqing Zhuang; Shujing Han; Qingqing Guo; Yanxia Luo; Jie Zhang; Xiaoxia Peng; Ling Zhang; Yuxiang Yan; Xinghua Yang; Hong Wang; Xu Han; Guangxu Liu; Youhou Kang; Youqin Liu; Shengfeng Weng; Hong Zhang; Xiaoqiang Zhang; Kebao Jia; Li Wang; Lei Zhao; Zongxin Xiao; Shuhua Zhang; Huihui Wu; Qingxuan Lai; Na Qi; Wei Wang; Gaisano Herbert; Fen Liu; Yan He*. An Exploratory Study of the Association between KCNB1 rs1051295 and type 2 diabetes and its related traits in chinese han population. Plos one, 2013, 8(2):e56365.
17.  Guoqing Zhuang#; Cong Meng#; Xin Guo; Patali S.Cheruku; Lei Shi; Hang Xu; Honggui Li; Gang Wang; Ashely R.Evans; Stephen Safe; Chaodong Wu*; Beiyan Zhou*. A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation. Circulation, 2012,125(23):2892-903. 
18.  Zhizhong Cui; Guoqin Zhuang; Xiaoyun Xu; Aijun Sun; Shuai Su; Molecular and biological characterization of a Marek's disease virus field strain with reticuloendotheliosis virus LTR insert, Virus Gene, 2010, 40(2):236-43. 
19.  Qizhu Tang; Jun Cai; Difei Shen; Zhouyan Bian; Ling Yan; Youxin Wang; Jie Lan; Guoqing Zhuang; Wenzhan Ma; Wei Wang*. Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling. Journal of Molecular Medicine, 2009,87(3):249-60.
20.  Guoqing Zhuang#; Wei Wu#; Fen Liu; Junli Ma; Yongxiang Luo; Zhenxing Xiao; Yan Liu; Wei Wang; Yan He*. SNAP-25(1-180) enhances insulin secretion by blocking Kv2.1 channels in rat pancreatic islet beta-cells. Biochem Biophys Res Commun, 2009,379(4):812-6.
21. Jie Lan; Manshu Song; Chunhui Pan; Guoqing Zhuang; Youxin Wang; Wenzhan Ma; Qiaoyun Chu; Qingxuan Lai; Fen Xu; Yanli Li; Lixin Liu; Wei Wang*. Association of genetic variations in dopaminergic genes (DAT and DRD2) with disorders of fluent speech in han chinese. Journal of Human Geneitics, 2009,54(8): 457-460.
1.2021年，河南省教育厅自然科学优秀论文1等奖
2.2021年，河南省人力资源与社会保障厅自然科学优秀论文2等奖
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