明胜利

姓名：明胜利
学科：基础兽医学
系别：动物生物技术系
电话/传真：
电子邮件：mingsl911102@163.com
通讯地址：郑州市郑东新区龙子湖高教园区15号 河南农业大学龙子湖校区第一实验楼动物医学院 450046

 

      明胜利，男，博士，硕士研究生导师。围绕动物繁殖障碍病毒的致病机理、病毒与宿主互作关系开展研究工作，主持国家自然科学基金青年科学基金项目（C类）、国家资助博士后研究人员计划、中国博士后科学基金面上项目各1项，参与国家自然科学基金面上项目1项；以（含共同）第一/通讯作者在 Autophagy、PLoS Pathogens、mBio、Journal of Virology和Virologica Sinica等国际期刊上发表多篇研究论文。获河南省教育厅优秀科技论文一等奖、河南省研究生创新之星、河南省博士后创新创业大赛二等奖等省部级荣誉。
动物繁殖障碍病毒与宿主的相互作用
本科生《动物生物化学》、《分子生物学》
硕士研究生《生物化学和分子生物学研究进展》、《兽医生物技术》、《动物生物化学进展》
博士研究生《兽医生物技术》
(1) 2019-09 至 2023-06, 河南农业大学, 动物医学院，博士研究生, 博士
(2) 2016-09 至 2019-06, 河南农业大学, 牧医工程学院，硕士研究生, 硕士
(3) 2012-09 至 2016-06, 河南农业大学, 牧医工程学院，本科，理学学士
2024年1月-至今 河南农业大学
(1) 国家自然科学基金委员会, 青年科学基金项目（C类）, 32503059, 猪伪狂犬病毒通过泛素化降解m⁶A阅读器YTHDF1抑制天然免疫关键分子表达的分子机制, 2026-01至2028-12, 30万元, 在研, 主持
(2) 中国博士后科学基金会, 面上项目, 2025M770267, 伪狂犬病毒通过促进ODF1相分离激活NLRP3炎性小体的分子机制, 2025-11至2027-12, 8万元, 在研, 主持
(3) 中国博士后科学基金会, 2024年度国家资助博士后研究人员计划C档资助, GZC20240430, 伪狂犬病毒通过下调m⁶A识别蛋白YTHDF1逃避天然免疫应答的分子机制, 2024-11至2026-12, 24万元, 在研, 主持
(4) 国家自然科学基金委员会, 面上项目, 32573380, 伪狂犬病毒通过促进ODF1相分离激活NLRP3炎性小体的分子机制, 2026-01至2029-12, 50万元, 在研, 参与
(1) Ying-Xian Ma^#, Jia-Ming Yang^#, Hang-Tian Mei, Lei Zeng, Guo-Yu Yang, Jiang Wang, Sheng-Li Ming^*, Bei-Bei Chu^*. Porcine reproductive and respiratory syndrome virus activates the pentose phosphate pathway via the ROS/HIF-1α/G6PD axis to promote viral replication. Virulence, 2025, 16(1):2585639.
(2) Ying-Xian Ma^#, Ya-Qi Han^#, Pei-Zhu Wang, Bei-Bei Chu, Sheng-Li Ming^*, Lei Zeng^*. Lycopene Inhibits PRRSV Replication by Suppressing ROS Production, International Journal of Molecular Sciences, 2025, 26(15):7560.
(3) Shi-Jun Zhang^#, Dan Su^#, Shi-Bo Zhao, Jia-You Xing, Lei Zeng, Jiang Wang, Sheng-Li Ming^*, Bei-Bei Chu^*. Isolation, Identification, and Genetic Evolution Analysis of VP1 Gene of Feline Calicivirus Strain ZZ202306. International Journal of Molecular Sciences, 2025, 26(6):2565.
(4) Lei Zeng^#, Shu-Yi Wang^#, Meng-Hua Du, Bei-Bei Chu^*, Sheng-Li Ming^*. The vitamin D receptor is essential for the replication of pseudorabies virus. mBio, 2024, 15(12): e0213724.
(5) Dong-Ge Liang^#, Yu-Kun Guo^#, Shi-Bo Zhao^#, Guo-Yu Yang, Ying-Qian Han, Bei-Bei Chu^*, Sheng-Li Ming^*, Pseudorabies virus hijacks the Rab6 protein to promote viral assembly and egress. Veterinary Research, 2024, 55(1): 68.
(6) Meng-Pan Cai^#, Cheng-Long Qu^#, Meng-Hua Du, Shu-Yi Wang, Guo-Yu Yang, Bei-Bei Chu^*, Sheng-Li Ming^*. Role of Rab35 in modulating lipid metabolism and viral entry during pseudorabies virus infection. International Journal of Biological Macromolecules, 2024, 282(Pt 6):137492.
(7) Bing-Qian Su, Guo-Yu Yang, Jiang Wang^*, Sheng-Li Ming^*, Bei- Bei Chu*. Pseudorabies virus inhibits progesterone-induced inactivation of TRPML1 to facilitate viral entry. PLOS Pathogens, 2024, 20(1): e1011956.
(8) Guo-Li Li^#, Ying-Qian Han^#, Bing-Qian Su, Hai-Shen Yu, Shuang Zhang, Guo-Yu Yang, Jiang Wang, Fang Liu*, Sheng-Li Ming^*, Bei-Bei Chu^*. Porcine reproductive and respiratory syndrome virus 2 hijacks CMA-mediated lipolysis through upregulation of small GTPase RAB18. PLOS Pathogens, 2024, 20(4):e1012123.
(9) Ying-Xian Ma^#, Ya-Jing Chai^#, Ya-Qi Han, Shi-Bo Zhao, Guo-Yu Yang, Jiang Wang^*, Sheng-Li Ming^*, Bei-Bei Chu*. Pseudorabies virus upregulates low-density lipoprotein receptors to facilitate viral entry. Journal of Virology, 2024;98(1):0-e0166423.
(10) Sheng-Li Ming^#, Shi-Jun Zhang^#, Jia-You Xing, Guo-Yu Yang, Lei Zeng, Jiang Wang^*, Bei-Bei Chu^*. Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication. iScience, 2024, 27(7): 110144.
(11) Xiu-Qing Li^#, Meng-Pan Cai^#, Ming-Yang Wang, Bo-Wen Shi, Guo-Yu Yang, Jiang Wang, Bei-Bei Chu^*, Sheng-Li Ming^*. Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication. Virologica Sinica, 2024, S1995-820X(24)00039-7.
(12) Shuang Zhang^#, Lei Zeng^#, Bing-Qian Su, Guo-Yu Yang, Jiang Wang^*, Sheng-Li Ming^*, Bei-Bei Chu*. The glycoprotein 5 of porcine reproductive and respiratory syndrome virus stimulates mitochondrial ROS to facilitate viral replication. mBio, 2023, 14(6): 0-e0265123.
(13) Shuang Zhang^#, Sheng-Li Ming^#, Lei Zeng Lu-Fang Wang, Chao Zhang, He-Shui Zhu, Guo-Yu Yang, Gai-Ping Zhang^*, Bei-Bei Chu^*, Jiang Wang^*. Alphaherpesvirus upregulates NDRG1 expression to facilitate the nuclear import of viral UL31 and UL34 proteins. Journal of Medical Virology, 2023, 95(3):e28591.
(14) Sheng-Li Ming^#, Shuang Zhang^#, Qi Wang^#, Lei Zeng, Lu-Yu Zhou, Meng-Di Wang, Ying-Xian Ma, Li-Qiang Han, Kai Zhong, He-Shui Zhu, Yi-Lin Bai, Guo-Yu Yang^*, Jiang Wang^*, Bei-Bei Chu^*. Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy. Autophagy, 2022, 18(8): 1801-1821.
(15) Yu-Kun Guo^#, Sheng-Li Ming^#, Lei Zeng, Wen-Ru Chang, Jia-Jia Pan, Chao Zhang, Bo Wan, Jiang Wang, Yu Su, Guo-Yu Yang*, Bei-Bei Chu^*. Inhibition of histone deacetylase 1 suppresses pseudorabies virus infection through cGAS-STING antiviral innate immunity. Molecular Immunology, 2021, 136:55-64.
(16) Lei Zeng^#, Meng-Di Wang^#, Sheng-Li Ming^#, Guo-Li Li, Peng-Wei Yu, Yan-Li Qi, Da-Wei Jiang, Guo-Yu Yang^*, Jiang Wang^*, Bei-Bei Chu^*. An effective inactivant based on singlet oxygen-mediated lipid oxidation implicates a new paradigm for broad-spectrum antivirals. Redox Biology, 2020, 36:101601.
(17) Sheng-Li Ming^#, Lei Zeng^#, Yu-Kun Guo, Shuang Zhang, Guo-Li Li, Ying-Xian Ma, Yun-Yun Zhai, Wen-Ru Chang, Le Yang, Jiang Wang^*, Guo-Yu Yang^*, Bei-Bei Chu^*. The human-specific STING agonist G10 activates type I interferon and the NLRP3 inflammasome in porcine cells. Frontiers in Immunology, 2020, 11:575818.
不积跬步，无以至千里；不积小流，无以成江海。