王江

姓名：王江
学科：基础兽医学
系别：动物生物技术系
电话/传真：
电子邮件：wangjiang@henau.edu.cn
通讯地址：河南农业大学龙子湖校区第一实验楼北405B 邮编 450046

      王江，男，博士，副教授，硕士研究生导师，中国科学院上海生物化学与细胞生物学研究所博士。
      教学上承担的动物生物化学课程，获得河南农业大学2015年度校级精品资源共享课。指导本科生从事科技创新，获得河南农业大学牧医工程学院第七届“大学生科技创新”活动“优秀指导教师奖”。2016年被授予河南农业大学牧医工程学院优秀教师称号。
      科研上近年来主持国家自然科学基金面上和青年基金项目和河南省基础研究计划，参与了转基因生物新品种培育重大专项、“十二五”农村领域国家科技计划、河南省重大科技专项、霍英东教育基金会高等院校青年教师基金和国家自然科学基金青年等项目。并在Cell、Cell Metabolism、Autophagy、Redox Biology、Plos Pathogens、Journal of Virology、Journal of Lipid Research等国际期刊上发表多篇原创性研究论文。获得国家发明专利2项，申请国家发明专利5项。
本科生《动物生物化学》《分子生物学》
硕士研究生《生物化学和分子生物学研究进展》、《兽医生物技术》、《畜牧生物技术专题》、《分子种系发育与生物信息学》、《动物生物化学进展》、《基因工程原理与技术》
博士研究生《兽医生物技术》
病毒与宿主相互作用。
2000.09-2004.06，兰州大学，生物科学专业， 学士                   
2004.09-2007.06，兰州大学，生物化学与分子生物学，硕士             
2008.09-2013.01，中科院生化细胞所，生物化学与分子生物学，博士                
2013.01-2015.11，河南农业大学牧医工程学院，博士后                  
2013.09-2017.12，河南农业大学牧医工程学院，讲师
2018.01-至今， 河南农业大学牧医工程学院，副教授
1. 国家自然科学基金面上项目：伪狂犬病毒通过抑制维甲酸合成代谢逃避宿主天然免疫应答的分子机制（32272961）2023.01-2026.12，主持
2. 兽医生物技术国家重点实验室开放课题：伪狂犬病毒重编程宿主细胞视黄醇代谢的分子机制（SKLVBF202205）2022.01-2023.12，主持
3. 国家自然科学基金青年项目：丙酮酸激酶M2对奶牛乳腺上皮细胞增殖和乳合成的影响（31402158）2015.01-2017.12，主持
4. 河南省基础研究计划：CRISPR-Cas新型基因敲除载体的构建及功能验证（142300413209）2014.02-2016.12，主持
1. Shuang Zhang, Sheng‐Li Ming, Lei Zeng, Lu‐Fang Wang, Chao Zhang, He‐Shui Zhu, Guo‐Yu Yang, Gai‐Ping Zhang*, Bei‐Bei Chu*, Jiang Wang*. Alphaherpesvirus upregulates NDRG1 expression to facilitate the nuclear import of viral UL31 and UL34 proteins. 2023, Journal of Medical Virology; 95(3):e28591. doi: 10.1002/jmv.28591.
2. Chao Tong, Peng-Fei Fu, Sheng-Li Ming, Lei Zeng, He-Shui Zhu*, Jiang Wang*. Acute transcriptomic changes in murine RAW 264.7 cells following pseudorabies virus infection. 2022, Archives of Virology; 167(12):2623-2631. doi: 10.1007/s00705-022-05598-1.
3. Peng-Wei Yu, Peng-Fei Fu, Lei Zeng, Yan-Li Qi, Xiu-Qing Li, Qi Wang, Guo-Yu Yang, Hua-Wei Li, Jiang Wang*, Bei-Bei Chu*, Meng-Di Wang*. EGCG Restricts PRRSV Proliferation by Disturbing Lipid Metabolism. 2022, Microbiology Spectrum; 10(2):e0227621. doi: 10.1128/spectrum.02276-21.
4. Peng-Fei Fu, Dong-Chang He, Xuan Cheng, Xin-Rui Niu, Cong-Rong Wang, Yi-Qian Fu, Kun Li, He-Shui Zhu, Wei-Fei Lu, Jiang Wang*, Bei-Bei Chu*. Prevalence and Characteristics of Canine Parvovirus Type 2 in Henan Province, China. 2022, Microbiology Spectrum; 10(6):e0185622. doi: 10.1128/spectrum.01856-22.
5. Sheng-Li Ming, Shuang Zhang, Qi Wang, Lei Zeng, Lu-Yu Zhou, Meng-Di Wang, Ying-Xian Ma, Li-Qiang Han, Kai Zhong, He-Shui Zhu, Yi-Lin Bai, Guo-Yu Yang, Jiang Wang*, Bei-Bei Chu*. Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress triggered selective autophagy. 2021, Autophagy; 18(8):1801-1821. doi: 10.1080/15548627.2021.2002101.
6. Guo-Li Li, Guang-Xu Ding, Lei Zeng, Sheng-Li Ming, Peng-Fei Fu, Qi Wang, Guo-Yu Yang, Jiang Wang*, Bei-Bei Chu*, Inhibition of PARP1 dampens pseudorabies virus infection through DNA-damage-induced antiviral innate immunity. 2021, Journal of Virology; 95(16):e0076021. doi: 10.1128/JVI.00760-21.
7. Lei Zeng, Meng-Di Wang, Sheng-Li Ming, Guo-Li Li, Peng-Wei Yu, Yan-Li Qia, Da-Wei Jiang, Guo-Yu Yang*, Jiang Wang*, Bei-Bei Chu*. An effective inactivant based on singlet oxygen-mediated lipid oxidation implicates a new paradigm for broad-spectrum antivirals. 2020, Redox Biology; 36:101601. doi: 10.1016/j.redox.2020.
8. Jiang Wang, Guo-Li Li, Sheng-Li Ming, Chun-Feng Wang, Li-Juan Shi1, Bing-Qian Su, Hong-Tao Wu, Lei Zeng, Ying-Qian Han, Zhong-Hu Liu, Da-Wei Jiang, Yong-Kun Du, Xiang-Dong Li, Gai-Ping Zhang, Guo-Yu Yang*, Bei-Bei Chu*. BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses. 2020, Plos Pathogens; 16(3):e1008429. doi: 10.1371/journal.ppat.1008429.
9. Jiang Wang, Gen Ba, Ying-Qian Han, Sheng-Li Ming, Meng-Di Wang, Peng-Fei Fu, Qing-Qing Zhao, Shuang Zhang, Ya-Nan Wu, Guo-Yu Yang*, Bei-Bei Chu*. Cyclic GMP-AMP Synthase Is Essential for Cytosolic Double-Stranded DNA and Fowl Adenovirus Serotype 4 Triggered Innate Immune Responses in Chickens. 2020, International Journal of Biological Macromolecules; 146:497-507. doi: 10.1016/j.ijbiomac.2020.01.015.
10. Shao-Ting Weng, Feng Gao, Juan Wang, Xing-Yu Li, Bei-Bei Chu, Jiang Wang*, Guo-Yu Yang*. Improvement of Muscular Atrophy by AAV-SaCas9-mediated Myostatin Gene Editing in Aged Mice. 2020, Cancer Gene Therapy; 27(12):960-975. doi: 10.1038/s41417-020-0178-7.
11. Sheng-Li Ming, Lei Zeng, Yu-Kun Guo, Shuang Zhang, Guo-Li Li, Ying-Xian Ma, Yun-Yun Zhai, Wen-Ru Chang, Le Yang, Jiang Wang, Guo-Yu Yang*, Bei-Bei Chu*.  The human specific STING agonist G10 activates type I interferon and the NLRP3 inflammasome in porcine cells. 2020, Frontiers in Immunology; 11:575818. doi: 10.3389/fimmu.2020.575818.
12. Jiang Wang, Jiao-Yang Liu, Ke-Yu Shao, Ying-Qian Han, Guo-Li Li, Sheng-Li Ming, Bing-Qian Su, Yong-Kun Du, Zhong-Hu Liu, Gai-Ping Zhang, Guo-Yu Yang*, Bei-Bei Chu*. PRRSV activates lipophagy to facilitate viral replication through down-regulation of NDRG1 expression. 2019, Journal of Virology; 93(17):e00526-19. doi: 10.1128/JVI.00526-19.
13. Jiang Wang, Chun-Feng Wang, Sheng-Li Ming, Guo-Li Li, Lei Zeng, Meng-Di Wang, Bing-Qian Su, Qi Wang, Guo-Yu Yang*, Bei-Bei Chu*. Porcine IFITM1 is a host restriction factor that inhibits pseudorabies virus infection. 2019, International Journal of Biological Macromolecules; 151:1181-1193. doi: 10.1016/j.ijbiomac.2019.10.162.
14. Ying-Qian Han, Sheng-Li Ming, Hong-Tao Wu, Lei Zeng, Gen Ba, Jian Li, Wei-Fei Lu, Jie Han, Qia-Jun Du, Miao-Miao Sun, Guo-Yu Yang*, Jiang Wang*, Bei-Bei Chu*. Myostatin Knockout Induces Apoptosis in Human Cervical Cancer cells via Elevated Reactive Oxygen Species Generation.2018, Redox Biology; 19:412-428. doi: 10.1016/j.redox.2018.09.009.
15. Jiang Wang, Shao-Fang Lu, Bo Wan, Sheng-Li Ming, Guo-Li Li, Bing-Qian Su, Jiao-Yang Liu,Yu-Shuang Wei, Guo-Yu Yang*, Bei-Bei Chu*. Maintenance of cyclic GMP–AMP homeostasis by ENPP1 is involved in pseudorabies virus infection. 2018, Molecular Immunology; 95:56-63. doi: 10.1016/j.molimm.2018.01.008.
16. Shao-Fang Lu, Ying-Qian Han, Zhen-Zhen Guo, Shuang-Shuang Fan, Li-Qiang Han, Bo Wan, Bei-Bei Chu, Guo-Yu Yang, Jiang Wang*. PKM2 knockdown influences SREBP activation and lipid synthesis in bovine mammary-gland epithelial MAC-T cells. 2018, Biotechnology Letters; 40(4):641-648. doi: 10.1007/s10529-018-2518-3.
17. Jiang Wang, Lei Zeng, Li Zhang, Zhen-Zhen Guo, Shao-Fang Lu, Sheng-Li Ming, Guo-Li Li, Bo Wan, Ke-Gong Tian, Guo-Yu Yang*, Bei-Bei Chu*. Cholesterol 25-Hydroxylase Acts as a Host Restriction Factor on Pseudorabies Virus Replication. 2017, Journal of General Virology; 98(6):1467-1476. doi: 10.1099/jgv.0.000797.
18. Bei-Bei Chu, Ya-Cheng Liao, Wei Qi, Chang Xie, Xi-Ming Du, Jiang Wang, Hong-Yuan Yang, Hong-Hua Miao, Bo-Liang Li*, Bao-Liang Song*. Cholesterol transport through lysosome-peroxisome membrane contacts. 2015, Cell; 161(2): 161(2):291-306. doi: 10.1016/j.cell.2015.02.019.
19. Jiang Wang, Bei-Bei Chu*, Li-Li Du, Ying-Qian Han, Xue-Mei Zhang, Shuang-Shuang Fan, Yue-Ying Wang, Guo-Yu Yang*. Molecular cloning and functional characterization of porcine cyclic GMP-AMP synthase. 2015, Molecular Immunology; 65(2):436-45. doi: 10.1016/j.molimm.2015.02.002.
20. Bei-Bei Chu^#, Jiang Wang^#, Yue-Ying Wang*, Guo-Yu Yang*. Knockdown of PKM2 induces apoptosis and autophagy in human alveolar adenocarcinoma A549 cells. 2015, Molecular Medicine Reports; 12(3): 4358-4363
21. Jiang Wang, Bei-Bei Chu, Liang Ge, Bo-Liang Li, Yan Yan*, Bao-Liang Song*.  Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption. 2009; Journal of Lipid Research; 50(8):1653-62. doi: 10.1194/jlr.M800669-JLR200.
Jian Cao, Jiang Wang, Wei Qi, Hong-Hua Miao, Jing Wang, Liang Ge, Russell A. DeBose-Boyd, Jing-Jie Tang, Bo-Liang Li*, Bao-Liang Song*. Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase. 2007, Cell Metabolism; 6(2):115-28. doi: 10.1016/j.cmet.2007.07.002.

1. 河南农业大学牧医工程学院第二届青年教师英语演讲赛一等奖(2014.05)
2. 河南农业大学牧医工程学院第七届“大学生科技创新”活动“优秀指导教师奖” (2015.06)
3. 河南农业大学2015年度校级精品资源共享课(2015.12)
4. 河南农业大学牧医工程学院2016年度优秀教师(2016.06)

国恩深沐自要强，谨慎言行勉作纲。德厚品高缘脉广，鹏程万里任翱翔。