杜向党

姓名：杜向党
学科：基础兽医学
系别：基础兽医系
电话/传真：
电子邮件：xddu@henau.edu.cn
通讯地址：郑州市郑东新区平安大道218号 河南农业大学动物医学院 450046

 

　　杜向党，博士，二级教授，河南省特聘教授，博士生导师。入选国家“万人计划”领军人才（2018），河南省高层次人才（ B类），河南省优秀专家等。兼任第六、七届中国兽药典委员会委员，第一届全国兽药评审咨询专家库成员，农业部第七届兽药评审专家，国家自然基金同行评议专家，中国畜牧兽医学会兽医药理毒理学分会副理事长，中国畜牧兽医学会兽医食品卫生学分会常务理事等。先后在澳大利亚蒙纳士大学、新西兰梅西大学做访问学者。
      主要从事病原菌耐药与新兽药创制工作，先后主持承担国家自然科学基金6项（含区域创新联合基金重点项目1项），十四五重点研发课题，国家特支计划，科技部高端外国专家引进计划，河南省高校科技创新团队计划、企业横向转化等。在 Lancet Infect Dis（IF 27.5）、Clin Microbiol Rev（IF 50.1）、Clin Microbiol Infect（IF 14.2）等期刊发表SCI论文62篇，主、参编（译）著作7部，参与研制三类新兽药4个，获河南省科技进步二等奖1项，先后5次荣获河南省优秀硕士论文指导教师。
1. 药物分析、兽医药物分析、药学导论（本科生）
2. 兽医英文与写作（硕士生）
3. 兽医科学进展（博士生）
病原菌耐药与致病机制；
新兽药创制
2000.09-2005.07，中国农业大学，动物医学院，博士
1996.09-2000.07，中国农业大学，动物医学院，本科
2017.02-至今，河南农业大学，教授/博士生导师
2016-2021，河南农业大学，河南省特聘教授
2015.06-2015.09，新西兰梅西大学，访问学者
2013.12-至今，河南农业大学，教授
2010.09-2011.09，澳大利亚蒙纳士大学，访问学者
2007.11-2013.12，河南农业大学，副教授
2005.07-2007.11，河南农业大学，讲师
第六、七届中国兽药典委员会委员，第七届农业部兽药评审专家，第一届全国兽药评审咨询专家库成员，国家自然基金同行评议专家，中国畜牧兽医学会兽医药理毒理学分会副理事长，中国畜牧兽医学会兽医食品卫生学分会常务理事等
主持承担国家自然基金6项（含区域创新重点项目1项），十四五重点研发课题，国家特支计划，科技部高端外国专家引进计划，河南省高校科技创新团队计划、企业横向转化等
[1]Yu R, Li L, Zou C, Chen Z, Schwarz S, Chen S, Xu C, Yao H, Du XD*. Emergence of high-level tigecycline resistance due to the amplification of a tet(A) gene variant in clinical carbapenem-resistant Klebsiella pneumoniae. Clin Microbiol Infect. 2023 Aug 5:S1198-743X(23)00358-0.(*corresponding author)
[2]C Li*, Y Wu, Y Chen, C Xu, H Yao, W  Yu, Z Wang, XD Du*. Violet phosphorene nanosheets coupled with CRISPR/Cas12a in a biosensor with a low background signal for onsite detection of tigecycline-resistant hypervirulent Klebsiella pneumonia. Sensors and Actuators: B. Chemical. 2023,Volume 395, November 15, 134509
[3]Yao H, Zhou R, Wang J, Wei Y, Li S, Zhang Z, Du XD*, Wu S*, Shi J*. Pathogen-Targeting Bimetallic Nanozymes as Ultrasonic-Augmented ROS Generator against Multidrug Resistant Bacterial Infection. Adv Healthc Mater. 2023 Jul 11:e2300449.
[4]Hao WB, Gu X, Yu X, Zhao Y, Li C, Jia M, Du XD*. Laccase Lac-W detoxifies aflatoxin B₁ and degrades five other major mycotoxins in the absence of redox mediators. Environ Pollut. 2023 Dec 1;338:122581. 
[5]Yao H, Xing H, Wang N, Zhang L, Schwarz S, Li C, Cai C, Xu C*, Du XD*. IS257-mediated amplification of tet(L) variant as a novel mechanism of enhanced tigecycline resistance in Staphylococcus cohnii. Res Microbiol. 2023 Aug 10:104114. 
[6]Tang B, Zou C, Schwarz S, Xu C, Hao W, Yan XM, Huang Y, Ni J, Yang H, Du XD*, Shan X*. Linezolid-Resistant Enterococcus faecalis of Chicken Origin Harbored Chromosome-Borne optrA and Plasmid-Borne cfr, cfr(D), and poxtA2 Genes. Microbiol Spectr. 2023 Jun 15;11(3):e0274122.
[7]Li W, Jiao D, Kang J, Yu R, Zhao W, Xu C, Li R, Du XD*, Yao H*. Emergence of lnu(C) variant conferring lincomycin resistance in Campylobacter coli of chicken origin. Int J Food Microbiol. 2023,388:110098. 
[8]Shan X, Yao H, Schwarz S, Li D, Li XS*, Du XD*. Excision and integration of unconventional circularizable structures involving the erm(B) gene in enterococci. Vet Microbiol. 2022,273:109542.
[9]Shan X, Li XS, Schwarz S, Chen Y, Xu C*, Du XD*. Plasmid-assisted horizontal transfer of a large lsa(E)-carrying genomic island in Enterococcus faecalis. Microbiol Spectr. 2022,10(4):e0015422. 
[10]Zhao W, Li W, Du XD*, Yao H*. Hybrid IncFIA/FIB/FIC(FII) plasmid co-carrying bla_NDM-5 and fosA3 from an Escherichia coli ST117 strain of retail chicken. Int J Food Microbiol. 2022,382:109914.  
[11]Wang Z, Liu X, Shi Z, Zhao R, Ji Y, Tang F, Guan Y, Feng X, Sun C, Lei L, Han W, Du XD*, Gu J*. A novel lysin Ply1228 provides efficient protection against Streptococcus suis type 2 infection in a murine bacteremia model. Vet Microbiol. 2022,268:109425. 
[12]Yu R, Chen Z, Li D, Schwarz S, Wang X*, Du XD*. Studies on the transmission of a tigecycline resistance-mediating tet(A) gene variant from Enterobacter hormaechei via a two-step recombination process. Microbiol Spectr. 2022,10(3):e0049622.
[13]Wang Z, Liu X, Shi Z, Zhao R, Ji Y, Tang F, Guan Y, Feng X, Sun C, Lei L, Han W, Du XD*, Gu J*. A novel lysin Ply1228 provides efficient protection against Streptococcus suis type 2 infection in a murine bacteremia model. Vet Microbiol. 2022,268:109425. 
[14]Xu C, Wang N, Li D, Schwarz S, Du XD*. Recombination events that occur in a poxtA-carrying Enterococcus faecium during the conjugation process. J Antimicrob Chemother. 2022,77(5):1228-1236. 
[15]Shan X, Yang M, Wang N, Schwarz S, Li D*, Du XD*. Plasmid fusion and recombination events that occurred during conjugation of poxtA-carrying plasmids in enterococci. Microbiol Spectr. 2022,10(1):e0150521.
[16]Yu R, Xu Y, Schwarz S, Shang Y, Yuan X, Zhang Y, Li D*, Du XD*. erm(T)-mediated macrolide-lincosamide resistance in Streptococcus suis. Microbiol Spectr. 2022,10(1):e0165721. 
[17]Yu R, Chen Z, Schwarz S, Yao H*, Du XD*. Mobilization of tet(X4) by IS1 family elements in porcine Escherichia coli isolates. Antimicrob Agents Chemother. 2022,66(1):e0159721.
[18]Wang N, Li D, Schwarz S, Qin S, Yao H*, Du XD*. Novel Tet(L) efflux pump variants conferring resistance to tigecycline and eravacycline in Staphylococcus spp. Microbiol Spectr. 2021,9(3):e0131021. 
[19]Zhao W, Li S, Schwarz S, Li A, Yao H, Du XD*. Detection of a NDM-5-producing Klebsiella pneumoniae sequence type 340 (CG258) high-risk clone in swine. Vet Microbiol. 2021,262:109218.
[20]Schwarz S, Zhang W, Du XD, Krüger H, Feßler AT, Ma S, Zhu Y, Wu C, Shen J, Wang Y. Mobile oxazolidinone resistance genes in Gram-positive and Gram-negative bacteria. Clin Microbiol Rev. 2021,34(3):e0018820.
[21]Yao H, Zhao W, Jiao D, Schwarz S, Zhang R, Li XS, Du XD*. Global distribution, dissemination and overexpression of potent multidrug efflux pump RE-CmeABC in Campylobacter jejuni. J Antimicrob Chemother. 2021,76(3):596-600.
[22]Yao H, Jiao D, Zhao W, Li A, Li R, Du XD*. Emergence of a novel tet(L) variant in Campylobacter spp. of chicken origin in China. Antimicrob Agents Chemother. 2020,65(1):e01622-20.
[23]Shan X, Li XS, Wang N, Schwarz S, Zhang SM, Li D, Du XD*. Studies on the role of IS1216E in the formation and dissemination of poxtA-carrying plasmids in an Enterococcus faecium clade A1 isolate. J Antimicrob Chemother. 2020,75(11):3126-3130.
[24]Qin S, Zhang C, Schwarz S, Li L, Dong H, Yao H, Du XD*. Identification of a novel conjugative mcr-8.2-bearing plasmid in an almost pan-resistant hypermucoviscous Klebsiella pneumoniae ST11 isolate with enhanced virulence. J Antimicrob Chemother. 2020,75(9):2696-2699.
[25]Yang M, Li XS, Li D, Shang Y, Yu R, Schwarz S, Huang Z, Du XD*. Two novel lsa(E)-carrying mobile genetic elements in Streptococcus suis. J Antimicrob Chemother. 2020, 75(9):2689-2691.
[26]Yao H, Li A, Yu R, Schwarz S, Dong H, Du XD*. Multiple copies of bla_NDM-5 located on conjugative megaplasmids from porcine Escherichia coli sequence type 218 isolates. Antimicrob Agents Chemother. 2020,64(5):e02134-19.
[27]Yan H, Yu R, Li D, Shi L, Schwarz S, Yao H, Li XS, Du XD*. A novel multiresistance gene cluster located on a plasmid-borne transposon in Listeria monocytogenes. J Antimicrob Chemother. 2020,75(4):868-872.
[28]Li D, Cheng Y, Schwarz S, Yang M, Du XD*. Identification of a poxtA- and cfr- carrying multiresistant Enterococcus hirae strain. J Antimicrob Chemother. 2020,75(2):482-484.
[29]Shang Y, Li D, Shan X, Schwarz S, Zhang SM, Chen YX, Ouyang W, Du XD*. Analysis of two pheromone-responsive conjugative multiresistance plasmids carrying the novel mobile optrA locus from Enterococcus faecalis. Infect Drug Resist. 2019,12:2355-2362.
[30]Shang Y, Li D, Hao W, Schwarz S, Shan X, Liu B, Zhang SM, Li XS, Du XD*. A prophage and two ICESa2603-family integrative and conjugative elements (ICEs) carrying optrA in Streptococcus suis. J Antimicrob Chemother. 2019,74(10):2876-2879.
[31]Li D, Li XY, Schwarz S, Yang M, Zhang SM, Hao W, Du XD*. Tn6674 is a novel enterococcal optrA-carrying multiresistance transposon of the Tn554 family. Antimicrob Agents Chemother. 2019,63(9):e00809-19.
[32]Hao W, Shan X, Li D, Schwarz S, Zhang SM, Li XS, Du XD*. Analysis of a poxtA-and optrA-co-carrying conjugative multiresistance plasmid from Enterococcus faecalis. J Antimicrob Chemother. 2019,4(7):1771-1775.
[33]Yao H, Qin S, Chen S, Shen J, Du XD*. Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae. Lancet Infect Dis. 2018,18(1):25.
[34]Zhu XQ, Wang XM, Li H, Shang YH, Pan YS, Wu CM, Wang Y, Du XD*, Shen JZ. Novel lnu(G) gene conferring resistance to lincomycin by nucleotidylation, located on Tn6260 from Enterococcus faecalis E531. J Antimicrob Chemother. 2017,72(4):993-997.
河南省科技进步二等奖
1.国家“万人计划”领军人才，2018
2.科技部中青年科技创新领军人才，2016
3.河南省特聘教授，2016
好奇心是创新的源泉