
学科:基础兽医学
系别:基础兽医系
电话/传真:
电子邮件:xddu@henau.edu.cn
通讯地址:郑州市郑东新区龙子湖15号 河南农业大学龙子湖校区动物医学院 450046
简介
杜向党,博士,二级教授,河南省特聘教授,博士生导师。入选国家“万人计划”领军人才(2018),河南省高层次人才( B类),河南省优秀专家等。兼任第六、七届中国兽药典委员会委员,农业部第七届兽药评审专家,第一届全国兽药评审咨询专家库成员,国家自然基金同行评议专家,中国畜牧兽医学会兽医药理毒理学分会常务理事,兽医食品卫生学分会常务理事等。先后在澳大利亚蒙纳士大学、新西兰梅西大学做访问学者。主要从事病原菌耐药与新兽药创制工作,先后主持承担国家特支计划,国家自然基金5项, 973计划子课题,科技部高端外国专家引进计划,河南省高校科技创新团队计划等。在 Lancet Infect Dis(IF 25.148)、Clin Microbiol Rev(IF 26.132)、Microbiol Spectr(IF 7.171)、J Antimicrob Chemother(IF 5.790)、Antimicrob Agents Chemother(IF 5.191)等期刊发表SCI论文51篇,主、参编(译)著作7部,参与研制三类新兽药4个,获河南省科技进步二等奖1项,先后4次荣获河南省优秀硕士论文指导教师。
教授课程
1. 药物分析、兽医药物分析、药学导论(本科生)2. 新药研发与细菌耐药性专题(硕士生)
3. 兽医科学进展(博士生)
研究领域
病原菌耐药与致病机制;新兽药创制
学历及培训经历
2000.09-2005.07,中国农业大学,动物医学院,博士1996.09-2000.07,中国农业大学,动物医学院,本科
工作经历
2017.02-至今,河南农业大学,教授、博士生导师2016.04-至今,河南农业大学,河南省特聘教授
2015.06-2015.09,新西兰梅西大学,访问学者
2013.12-至今,河南农业大学,教授
2010.09-2011.09,澳大利亚蒙纳士大学,访问学者
2007.11-2013.12,河南农业大学,副教授
2005.07-2007.11,河南农业大学,讲师
学术社会兼职
第六、七届中国兽药典委员会委员,第七届农业部兽药评审专家,第一届全国兽药评审咨询专家库成员,国家自然基金同行评议专家,中国畜牧兽医学会兽医药理毒理学分会常务理事,中国畜牧兽医学会兽医食品卫生学分会常务理事等
承担科研项目情况
主持国家自然基金(5项)、国家特支计划、科技部高端外国专家引进计划,河南省高校科技创新人才及团队计划等
代表论著(*通讯作者)
[1] Li W, Jiao D, Kang J, Yu R, Zhao W, Xu C, Li R, Du XD*, Yao H*. Emergence of lnu(C) variant conferring lincomycin resistance in Campylobacter coli of chicken origin. Int J Food Microbiol. 2023,388:110098. (*corresponding author)[2] Shan X, Yao H, Schwarz S, Li D, Li XS*, Du XD*. Excision and integration of unconventional circularizable structures involving the erm(B) gene in enterococci. Vet Microbiol. 2022,273:109542.
[3] Shan X, Li XS, Schwarz S, Chen Y, Xu C*, Du XD*. Plasmid-assisted horizontal transfer of a large lsa(E)-carrying genomic island in Enterococcus faecalis. Microbiol Spectr. 2022,10(4):e0015422.
[4] Li A, Yu R, Zhao W, Schwarz S, Li C, Yao H*, Du XD*. Characterization of a genomic Island carrying the tet(X4) gene in porcine Acinetobacter towneri co-harboring plasmid-borne blaNDM-1 and blaOXA-58 genes. Front Vet Sci. 2022,9:1002149.
[5] Zhao W, Li W, Du XD*, Yao H*. Hybrid IncFIA/FIB/FIC(FII) plasmid co-carrying blaNDM-5 and fosA3 from an Escherichia coli ST117 strain of retail chicken. Int J Food Microbiol. 2022,382:109914.
[6] Wang Z, Liu X, Shi Z, Zhao R, Ji Y, Tang F, Guan Y, Feng X, Sun C, Lei L, Han W, Du XD*, Gu J*. A novel lysin Ply1228 provides efficient protection against Streptococcus suis type 2 infection in a murine bacteremia model. Vet Microbiol. 2022,268:109425.
[7] Yu R, Chen Z, Li D, Schwarz S, Wang X*, Du XD*. Studies on the transmission of a tigecycline resistance-mediating tet(A) gene variant from Enterobacter hormaechei via a two-step recombination process. Microbiol Spectr. 2022,10(3):e0049622.
[8] Xu C, Wang N, Li D, Schwarz S, Du XD*. Recombination events that occur in a poxtA-carrying Enterococcus faecium during the conjugation process. J Antimicrob Chemother. 2022,77(5):1228-1236.
[9] Shan X, Yang M, Wang N, Schwarz S, Li D*, Du XD*. Plasmid fusion and recombination events that occurred during conjugation of poxtA-carrying plasmids in enterococci. Microbiol Spectr. 2022,10(1):e0150521.
[10] Yu R, Xu Y, Schwarz S, Shang Y, Yuan X, Zhang Y, Li D*, Du XD*. erm(T)-mediated macrolide-lincosamide resistance in Streptococcus suis. Microbiol Spectr. 2022,10(1):e0165721.
[11] Yu R, Chen Z, Schwarz S, Yao H*, Du XD*. Mobilization of tet(X4) by IS1 family elements in porcine Escherichia coli isolates. Antimicrob Agents Chemother. 2022,66(1):e0159721.
[12] Wang N, Li D, Schwarz S, Qin S, Yao H*, Du XD*. Novel Tet(L) efflux pump variants conferring resistance to tigecycline and eravacycline in Staphylococcus spp. Microbiol Spectr. 2021,9(3):e0131021.
[13] Yu R, Zhang Y, Xu Y, Schwarz S, Li XS, Shang YH, Du XD*. Emergence of a tet(M) Variant Conferring Resistance to Tigecycline in Streptococcus suis. Front Vet Sci. 2021,8:709327.
[14] Zhao W, Li S, Schwarz S, Li A, Yao H, Du XD*. Detection of a NDM-5-producing Klebsiella pneumoniae sequence type 340 (CG258) high-risk clone in swine. Vet Microbiol. 2021,262:109218.
[15] Schwarz S, Zhang W, Du XD, Krüger H, Feßler AT, Ma S, Zhu Y, Wu C, Shen J, Wang Y. Mobile oxazolidinone resistance genes in Gram-positive and Gram-negative bacteria. Clin Microbiol Rev. 2021,34(3):e0018820.
[16] Yao H, Zhao W, Jiao D, Schwarz S, Zhang R, Li XS, Du XD*. Global distribution, dissemination and overexpression of potent multidrug efflux pump RE-CmeABC in Campylobacter jejuni. J Antimicrob Chemother. 2021,76(3):596-600.
[17] Yao H, Jiao D, Zhao W, Li A, Li R, Du XD*. Emergence of a novel tet(L) variant in Campylobacter spp. of chicken origin in China. Antimicrob Agents Chemother. 2020,65(1):e01622-20.
[18] Shan X, Li XS, Wang N, Schwarz S, Zhang SM, Li D, Du XD*. Studies on the role of IS1216E in the formation and dissemination of poxtA-carrying plasmids in an Enterococcus faecium clade A1 isolate. J Antimicrob Chemother. 2020,75(11):3126-3130.
[19] Yao H, Cheng J, Li A, Yu R, Zhao W, Qin S, Du XD*. Molecular characterization of an IncFIIk plasmid co-harboring blaIMP-26 and tet(A) variant in a clinical Klebsiella pneumoniae isolate. Front Microbiol. 2020,11:1610.
[20] Qin S, Zhang C, Schwarz S, Li L, Dong H, Yao H, Du XD*. Identification of a novel conjugative mcr-8.2-bearing plasmid in an almost pan-resistant hypermucoviscous Klebsiella pneumoniae ST11 isolate with enhanced virulence. J Antimicrob Chemother. 2020,75(9):2696-2699.
[21] Yang M, Li XS, Li D, Shang Y, Yu R, Schwarz S, Huang Z, Du XD*. Two novel lsa(E)-carrying mobile genetic elements in Streptococcus suis. J Antimicrob Chemother. 2020, 75(9):2689-2691.
[22] Yao H, Li A, Yu R, Schwarz S, Dong H, Du XD*. Multiple copies of blaNDM-5 located on conjugative megaplasmids from porcine Escherichia coli sequence type 218 isolates. Antimicrob Agents Chemother. 2020,64(5):e02134-19.
[23] Yan H, Yu R, Li D, Shi L, Schwarz S, Yao H, Li XS, Du XD*. A novel multiresistance gene cluster located on a plasmid-borne transposon in Listeria monocytogenes. J Antimicrob Chemother. 2020,75(4):868-872.
[24] Li D, Cheng Y, Schwarz S, Yang M, Du XD*. Identification of a poxtA- and cfr- carrying multiresistant Enterococcus hirae strain. J Antimicrob Chemother. 2020,75(2):482-484.
[25] Shang Y, Li D, Shan X, Schwarz S, Zhang SM, Chen YX, Ouyang W, Du XD*. Analysis of two pheromone-responsive conjugative multiresistance plasmids carrying the novel mobile optrA locus from Enterococcus faecalis. Infect Drug Resist. 2019,12:2355-2362.
[26] Shang Y, Li D, Hao W, Schwarz S, Shan X, Liu B, Zhang SM, Li XS, Du XD*. A prophage and two ICESa2603-family integrative and conjugative elements (ICEs) carrying optrA in Streptococcus suis. J Antimicrob Chemother. 2019,74(10):2876-2879.
[27] Li D, Li XY, Schwarz S, Yang M, Zhang SM, Hao W, Du XD*. Tn6674 is a novel enterococcal optrA-carrying multiresistance transposon of the Tn554 family. Antimicrob Agents Chemother. 2019,63(9):e00809-19.
[28] Hao W, Shan X, Li D, Schwarz S, Zhang SM, Li XS, Du XD*. Analysis of a poxtA-and optrA-co-carrying conjugative multiresistance plasmid from Enterococcus faecalis. J Antimicrob Chemother. 2019,4(7):1771-1775.
[29] Yao H, Qin S, Chen S, Shen J, Du XD*. Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae. Lancet Infect Dis. 2018,18(1):25.
[30] Zhu XQ, Wang XM, Li H, Shang YH, Pan YS, Wu CM, Wang Y, Du XD*, Shen JZ. Novel lnu(G) gene conferring resistance to lincomycin by nucleotidylation, located on Tn6260 from Enterococcus faecalis E531. J Antimicrob Chemother. 2017,72(4):993-997.
成果奖励
河南省科技进步二等奖
荣誉称号
1. 国家“万人计划”领军人才,20182. 河南省特聘教授,2016
寄语动医学子
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