杜向党

姓名：杜向党
学科：基础兽医学
系别：基础兽医系
电话/传真：0371-56990161
电子邮件：xddu@henau.edu.cn
通讯地址：郑州市郑东新区平安大道218号 河南农业大学动物医学院 450046

　　杜向党，博士，二级教授，河南省特聘教授，博士生导师。入选国家高层人才计划，河南省高层次人才（B类），河南省优秀专家等。兼任中国畜牧兽医学会兽医药理毒理学分会副理事长，第六、七届中国兽药典委员会委员，第一届全国兽药评审咨询专家库成员，农业部第七届兽药评审专家，国家自然基金同行评议专家等。先后在英国纽卡斯尔大学、澳大利亚蒙纳士大学、新西兰梅西大学做访问学者。
      主要从事病原菌耐药与新兽药创制工作，先后主持承担国家自然科学基金7项（含区域创新联合基金重点项目1项），十四五重点研发课题，国家特支计划，科技部高端外国专家引进计划，河南省高校科技创新团队计划、企业横向课题和转化项目等。在Sci Adv（IF 12.5）、Lancet Infect Dis（IF 27.5）、Clin Microbiol Rev（IF 50.1）、Clin Microbiol Infect（IF 14.2）等期刊发表SCI论文84篇，主、参编（译）著作7部，参与研制三类新兽药4个，获河南省科技进步二等奖1项，湖北省技术发明二等奖1项。

1. 药物分析、兽医药物分析、药学导论（本科生）
2. 兽医英文与写作（硕士生）
3. 兽医科学进展（博士生）

病原菌耐药与致病机制；
新兽药创制

2000.09-2005.07，中国农业大学，动物医学院，博士
1996.09-2000.07，中国农业大学，动物医学院，本科

2017.02-至今，河南农业大学，教授/博士生导师
2016-2021，河南农业大学，河南省特聘教授
2015.06-2015.09，新西兰梅西大学，访问学者
2013.12-至今，河南农业大学，教授
2010.09-2011.09，澳大利亚蒙纳士大学，访问学者
2007.11-2013.12，河南农业大学，副教授
2005.07-2007.11，河南农业大学，讲师

中国畜牧兽医学会兽医药理毒理学分会副理事长，第六、七届中国兽药典委员会委员，第一届全国兽药评审咨询专家库成员，农业部第七届兽药评审专家，国家自然基金同行评议专家等

主持承担国家自然基金6项（含区域创新重点项目1项），十四五重点研发课题，国家特支计划，科技部高端外国专家引进计划，河南省高校科技创新团队计划、企业横向转化等

[1] Chen Z, Liu Y, Du C, Gao S, Zhai L, Schwarz S, Liu W, Li Q, Li L, Yu R, Zhao Y, Yao H, Luo L, Liu X, Xu C, Du XD*. Evolutionary Origins and Virulence Determinants of ST25 Hypervirulent Klebsiella pneumoniae in Swine: Genomic Insights and Functional Validation. Transbound Emerg Dis. 2026 Jan 21;2026:4488875. (corresponding author)

[2] Yu R, Chen Z, Schwarz S, Yao H, Li C, Du XD*. Formation of a novel multiresistance plasmid co-carrying tigecycline, carbapenem, and other resistance genes by recombination during conjugative transfer in Klebsiella pneumoniae. Int J Antimicrob Agents. 2026 Feb;67(2):107683.

[3] Zou C, Xu C, Shang Y, Yu R, Shan X, Schwarz S, Li D, Du XD*. Mechanism of horizontal transmission of tet(A)TIG multicopy structures in Escherichia coli of chicken origin. Vet Microbiol. 2026 Jan;312:110809.

[4] Zhao W, Du C, Chen Z, Zhao Y, Schwarz S, Yao H, Li C, Xu C*, Du XD*. Identification of the Genetic Basis of Phage Resistance in Sequentially Generated Phage-Resistant Klebsiella pneumoniae Using an Established Phage Library. Antibiotics (Basel). 2025 Oct 22;14(11):1056.

[5] Wu L, Zhang L, Wang X, Huang W, Schwarz S, Brenciani A, Li C*, Du XD*. Streptococcus suis Serotype 14: A Nonnegligible Zoonotic Population. Transbound Emerg Dis. 2025 Aug 25;2025:5779652.

[6] Chen X, Song M, Tian L, Shan X, Mao C, Chen M, Zhao J, Sami A, Yin H, Ali U, Shi J, Li H, Zhang Y, Zhang J, Wang S, Shi CL, Chen Y, Du XD*, Zhu K*, Wu L*. A plant peptide with dual activity against multidrug-resistant bacterial and fungal pathogens. Sci Adv. 2025 Mar 21;11(12):eadt8239.

[7] Kang J, Wan S, Zhao W, Li S, Li W, Li H, Liu Y, Huang H, Xu C, Du XD*, Yao H*. Characterization of cross-resistance gene optrA-carrying Campylobacter coli. Vet Microbiol. 2025 May;304:110476.

[8] Xing H, Zhang L, Li C, Schwarz S, Li D, Du XD*. Identification of a mepR mutation associated with tigecycline resistance in a clinical Staphylococcus aureus isolate. J Antimicrob Chemother. 2025 Apr 2;80(4):1059-1066.

[9] Shan X, Li C, Zhang L, Zou C, Yu R, Schwarz S, Shang Y, Li D, Brenciani A, Du XD*. poxtA amplification and mutations in 23S rRNA confer enhanced linezolid resistance in Enterococcus faecalis. J Antimicrob Chemother. 2024 Dec 2;79(12):3199-3203.

[10] Zou C, Xu C, Yu R, Shan X, Schwarz S, Li D, Du XD*. Tandem amplification of a plasmid-borne tet(A) variant gene confers tigecycline resistance in Escherichia coli. J Antimicrob Chemother. 2024 Jun 3;79(6):1294-1302.

[11] Yu R, Li L, Zou C, Chen Z, Schwarz S, Chen S, Xu C, Yao H, Du XD*. Emergence of high-level tigecycline resistance due to the amplification of a tet(A) gene variant in clinical carbapenem-resistant Klebsiella pneumoniae. Clin Microbiol Infect. 2023 Aug 5:S1198-743X(23)00358-0.

[12] C Li*, Y Wu, Y Chen, C Xu, H Yao, W Yu, Z Wang, XD Du*. Violet phosphorene nanosheets coupled with CRISPR/Cas12a in a biosensor with a low background signal for onsite detection of tigecycline-resistant hypervirulent Klebsiella pneumonia. Sensors and Actuators: B. Chemical. 2023,Volume 395,November 15, 134509

[13] Yao H, Zhou R, Wang J, Wei Y, Li S, Zhang Z, Du XD*, Wu S*, Shi J*. Pathogen-Targeting Bimetallic Nanozymes as Ultrasonic-Augmented ROS Generator against Multidrug Resistant Bacterial Infection. Adv Healthc Mater. 2023 Jul 11:e2300449.

[14] Hao WB, Gu X, Yu X, Zhao Y, Li C, Jia M, Du XD*. Laccase Lac-W detoxifies aflatoxin B1 and degrades five other major mycotoxins in the absence of redox mediators. Environ Pollut. 2023 Dec 1;338:122581.

[15] Yao H, Xing H, Wang N, Zhang L, Schwarz S, Li C, Cai C, Xu C*, Du XD*. IS257-mediated amplification of tet(L) variant as a novel mechanism of enhanced tigecycline resistance in Staphylococcus cohnii. Res Microbiol. 2023 Aug 10:104114.

[16] Tang B, Zou C, Schwarz S, Xu C, Hao W, Yan XM, Huang Y, Ni J, Yang H, Du XD*, Shan X*. Linezolid-Resistant Enterococcus faecalis of Chicken Origin Harbored Chromosome-Borne optrA and Plasmid-Borne cfr, cfr(D), and poxtA2 Genes. Microbiol Spectr. 2023 Jun 15;11(3):e0274122.

[17] Li W, Jiao D, Kang J, Yu R, Zhao W, Xu C, Li R, Du XD*, Yao H*. Emergence of lnu(C) variant conferring lincomycin resistance in Campylobacter coli of chicken origin. Int J Food Microbiol. 2023,388:110098.

[18] Shan X, Yao H, Schwarz S, Li D, Li XS*, Du XD*. Excision and integration of unconventional circularizable structures involving the erm(B) gene in enterococci. Vet Microbiol. 2022,273:109542.

[19] Shan X, Li XS, Schwarz S, Chen Y, Xu C*, Du XD*. Plasmid-assisted horizontal transfer of a large lsa(E)-carrying genomic island in Enterococcus faecalis. Microbiol Spectr. 2022,10(4):e0015422.

[20] Zhao W, Li W, Du XD*, Yao H*. Hybrid IncFIA/FIB/FIC(FII) plasmid co-carrying blaNDM-5 and fosA3 from an Escherichia coli ST117 strain of retail chicken. Int J Food Microbiol. 2022,382:109914.

[21] Wang Z, Liu X, Shi Z, Zhao R, Ji Y, Tang F, Guan Y, Feng X, Sun C, Lei L, Han W, Du XD*, Gu J*. A novel lysin Ply1228 provides efficient protection against Streptococcus suis type 2 infection in a murine bacteremia model. Vet Microbiol. 2022,268:109425.

[22] Yu R, Chen Z, Li D, Schwarz S, Wang X*, Du XD*. Studies on the transmission of a tigecycline resistance-mediating tet(A) gene variant from Enterobacter hormaechei via a two-step recombination process. Microbiol Spectr. 2022,10(3):e0049622.

[23] Wang Z, Liu X, Shi Z, Zhao R, Ji Y, Tang F, Guan Y, Feng X, Sun C, Lei L, Han W, Du XD*, Gu J*. A novel lysin Ply1228 provides efficient protection against Streptococcus suis type 2 infection in a murine bacteremia model. Vet Microbiol. 2022,268:109425.

[24] Xu C, Wang N, Li D, Schwarz S, Du XD*. Recombination events that occur in a poxtA-carrying Enterococcus faecium during the conjugation process. J Antimicrob Chemother. 2022,77(5):1228-1236.

[25] Shan X, Yang M, Wang N, Schwarz S, Li D*, Du XD*. Plasmid fusion and recombination events that occurred during conjugation of poxtA-carrying plasmids in enterococci. Microbiol Spectr. 2022,10(1):e0150521.

[26] Yu R, Xu Y, Schwarz S, Shang Y, Yuan X, Zhang Y, Li D*, Du XD*. erm(T)-mediated macrolide-lincosamide resistance in Streptococcus suis. Microbiol Spectr. 2022,10(1):e0165721.

[27] Yu R, Chen Z, Schwarz S, Yao H*, Du XD*. Mobilization of tet(X4) by IS1 family elements in porcine Escherichia coli isolates. Antimicrob Agents Chemother. 2022,66(1):e0159721.

[28] Wang N, Li D, Schwarz S, Qin S, Yao H*, Du XD*. Novel Tet(L) efflux pump variants conferring resistance to tigecycline and eravacycline in Staphylococcus spp. Microbiol Spectr. 2021,9(3):e0131021.

[29] Zhao W, Li S, Schwarz S, Li A, Yao H, Du XD*. Detection of a NDM-5-producing Klebsiella pneumoniae sequence type 340 (CG258) high-risk clone in swine. Vet Microbiol. 2021,262:109218.

[30] Schwarz S, Zhang W, Du XD, Krüger H, Feßler AT, Ma S, Zhu Y, Wu C, Shen J, Wang Y. Mobile oxazolidinone resistance genes in Gram-positive and Gram-negative bacteria. Clin Microbiol Rev. 2021,34(3):e0018820.

[31] Yao H, Zhao W, Jiao D, Schwarz S, Zhang R, Li XS, Du XD*. Global distribution, dissemination and overexpression of potent multidrug efflux pump RE-CmeABC in Campylobacter jejuni. J Antimicrob Chemother. 2021,76(3):596-600.

[32] Yao H, Jiao D, Zhao W, Li A, Li R, Du XD*. Emergence of a novel tet(L) variant in Campylobacter spp. of chicken origin in China. Antimicrob Agents Chemother. 2020,65(1):e01622-20.

[33] Shan X, Li XS, Wang N, Schwarz S, Zhang SM, Li D, Du XD*. Studies on the role of IS1216E in the formation and dissemination of poxtA-carrying plasmids in an Enterococcus faecium clade A1 isolate. J Antimicrob Chemother. 2020,75(11):3126-3130.

[34] Qin S, Zhang C, Schwarz S, Li L, Dong H, Yao H, Du XD*. Identification of a novel conjugative mcr-8.2-bearing plasmid in an almost pan-resistant hypermucoviscous Klebsiella pneumoniae ST11 isolate with enhanced virulence. J Antimicrob Chemother. 2020,75(9):2696-2699.

[35] Yang M, Li XS, Li D, Shang Y, Yu R, Schwarz S, Huang Z, Du XD*. Two novel lsa(E)-carrying mobile genetic elements in Streptococcus suis. J Antimicrob Chemother. 2020, 75(9):2689-2691.

[36] Yao H, Li A, Yu R, Schwarz S, Dong H, Du XD*. Multiple copies of blaNDM-5 located on conjugative megaplasmids from porcine Escherichia coli sequence type 218 isolates. Antimicrob Agents Chemother. 2020,64(5):e02134-19.

[37] Yan H, Yu R, Li D, Shi L, Schwarz S, Yao H, Li XS, Du XD*. A novel multiresistance gene cluster located on a plasmid-borne transposon in Listeria monocytogenes. J Antimicrob Chemother. 2020,75(4):868-872.

[38] Li D, Cheng Y, Schwarz S, Yang M, Du XD*. Identification of a poxtA- and cfr- carrying multiresistant Enterococcus hirae strain. J Antimicrob Chemother. 2020,75(2):482-484.

[39] Shang Y, Li D, Hao W, Schwarz S, Shan X, Liu B, Zhang SM, Li XS, Du XD*. A prophage and two ICESa2603-family integrative and conjugative elements (ICEs) carrying optrA in Streptococcus suis. J Antimicrob Chemother. 2019,74(10):2876-2879.

[40] Li D, Li XY, Schwarz S, Yang M, Zhang SM, Hao W, Du XD*. Tn6674 is a novel enterococcal optrA-carrying multiresistance transposon of the Tn554 family. Antimicrob Agents Chemother. 2019,63(9):e00809-19.

[41] Hao W, Shan X, Li D, Schwarz S, Zhang SM, Li XS, Du XD*. Analysis of a poxtA-and optrA-co-carrying conjugative multiresistance plasmid from Enterococcus faecalis. J Antimicrob Chemother. 2019,4(7):1771-1775.

[42] Yao H, Qin S, Chen S, Shen J, Du XD*. Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae. Lancet Infect Dis. 2018,18(1):25.

[43] Zhu XQ, Wang XM, Li H, Shang YH, Pan YS, Wu CM, Wang Y, Du XD*, Shen JZ. Novel lnu(G) gene conferring resistance to lincomycin by nucleotidylation, located on Tn6260 from Enterococcus faecalis E531. J Antimicrob Chemother. 2017,72(4):993-997.

河南省科技进步二等奖，湖北省技术发明二等奖

1.河南省科技进步二等奖，湖北省技术发明二等奖
2.科技部中青年科技创新领军人才，2016
3.河南省特聘教授，2016

好奇心是创新的源泉